A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson’s disease
Identifieur interne : 006238 ( Main/Exploration ); précédent : 006237; suivant : 006239A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson’s disease
Auteurs : Azadeh Seidi [Japon] ; Hirokazu Kaji [États-Unis, Japon] ; Nasim Annabi [Australie] ; Serge Ostrovidov [Japon] ; Murugan Ramalingam [Japon, France] ; Ali Khademhosseini [Japon, États-Unis]Source :
- Biomicrofluidics [ 1932-1058 ] ; 2011.
Abstract
In this study, we developed a miniaturized microfluidic-based high-throughput cell toxicity assay to create an
Url:
DOI: 10.1063/1.3580756
PubMed: 21799720
PubMed Central: 3145239
Affiliations:
- Australie, France, Japon, États-Unis
- Alsace (région administrative), Grand Est, Massachusetts, Nouvelle-Galles du Sud, Région de Tōhoku
- Cambridge (Massachusetts), Sendai, Strasbourg, Sydney
- Université Harvard, Université de Strasbourg, Université de Sydney, Université du Tōhoku
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>In this study, we developed a miniaturized microfluidic-based high-throughput cell toxicity assay to create an <italic>in vitro</italic>
model of Parkinson’s disease (PD). In particular, we generated concentration gradients of 6-hydroxydopamine (6-OHDA) to trigger a process of neuronal apoptosis in pheochromocytoma PC12 neuronal cell line. PC12 cells were cultured in a microfluidic channel, and a concentration gradient of 6-OHDA was generated in the channel by using a back and forth movement of the fluid flow. Cellular apoptosis was then analyzed along the channel. The results indicate that at low concentrations of 6-OHDA along the gradient (i.e., approximately less than 260 μM), the neuronal death in the channel was mainly induced by apoptosis, while at higher concentrations, 6-OHDA induced neuronal death mainly through necrosis. Thus, this concentration appears to be useful for creating an <italic>in vitro</italic>
model of PD by inducing the highest level of apoptosis in PC12 cells. As microfluidic systems are advantageous in a range of properties such as throughput and lower use of reagents, they may provide a useful approach for generating <italic>in vitro</italic>
models of disease for drug discovery applications.</p>
</div>
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<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Annabi, Nasim" sort="Annabi, Nasim" uniqKey="Annabi N" first="Nasim" last="Annabi">Nasim Annabi</name>
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<country name="France"><region name="Grand Est"><name sortKey="Ramalingam, Murugan" sort="Ramalingam, Murugan" uniqKey="Ramalingam M" first="Murugan" last="Ramalingam">Murugan Ramalingam</name>
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